Vol. 2, Issue 1, Part A (2025)

Sepsis is a life-threatening condition frequently encountered among oncology patients undergoing immunosuppressive therapy due to the compromised immune response. This paper explores comprehensive nursing strategies to detect, manage, and prevent sepsis in this vulnerable population. It begins by detailing the unique risks associated with immunosuppressive therapy, including neutropenia and mucosal barrier injury, which predispose patients to systemic infections. Early recognition through systematic monitoring of clinical signs such as fever, hypotension, tachycardia, and mental status changes is emphasized. Evidence-based interventions include timely administration of broad-spectrum antibiotics, strict adherence to infection control protocols, fluid resuscitation, and hemodynamic support. The role of nursing education, patient awareness, and interdisciplinary collaboration are also examined. Incorporating sepsis screening protocols, enhancing communication within care teams, and utilizing early warning systems have shown promising outcomes. Through case examples and current literature, this paper affirms that nurses play a pivotal role in mitigating sepsis-related morbidity and mortality among immunocompromised oncology patients.